Improving patient care and the health of our community through research and education.

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The Minneapolis Medical Research Foundation (MMRF) is a subsidiary of Hennepin Healthcare System, Inc., and operates as the research arm of Hennepin County Medical Center, an acute care research and teaching hospital in Minneapolis. MMRF is the third-largest nonprofit medical research organization in Minnesota and consistently ranks in the top ten percent of all institutions receiving research funding from the National Institutes of Health.

Learn more about our research programs.


Posted on November 18, 2016
BRINK study finds patients with moderate chronic kidney disease (CKD) have increased risk for dementia
Approximately 3 million patients live with this level of CKD in the United States

brainimagePatients with moderate chronic kidney disease (CKD), who have lost more than half of their kidney function score worse on tests of memory and decision-making skills than those without CKD, according to the BRain IN Kidney disease (BRINK) study.

Approximately 3 million people live with moderate CKD in the United States, more often affecting the elderly. In patients with CKD their kidneys are no longer functioning at full capacity, but they don’t yet need dialysis.

“What I and others have found is that as kidney function declines, so does brain function,” Dr. Anne Murray, Principal Investigator of the BRINK study said. Patients with CKD have a 50-60 percent increased risk of dementia. (Read the full story about the BRINK study)


Posted on November 18, 2016
November is Alzheimer’s Disease & Caregiver Awareness Month

the Healthy Matters logoAlzheimer’s disease is the most common type of dementia, accounting for at least 60 percent of dementia cases, and is the sixth leading cause of death in the United States, according to the Alzheimer’s Association. In recognition of Alzheimer’s Awareness Month, MMRF researcher Dr. Anne Murray was recently the featured guest on the Healthy Matters radio broadcast on WCCO. Dr. Murray and host Dr. David Hilden talked about Alzheimer’s and other types of dementia and the latest in research including the BRain IN Kidney disease (BRINK) study, which is investigating the connection between dementia and chronic kidney disease.

To listen to a podcast of the program, click on the Healthy Matters logo above and choose the episode from November 13. You can also read more on My Healthy Matters blog. To learn more about Alzheimer’s and dementia, visit the Alzheimer’s Association.

New policy on the dissemination of NIH-funded clinical trial information goes into effect January 18, 2017

image of the new NIH policy logoEarly next year, the National Institutes of Health (NIH) will expand its registration requirement to all clinical trials funded in whole or in part by the NIH. NIH funded Principal Investigators will now be expected to ensure that all trials are registered at, and that the studies’ summary results information is submitted to site in a timely manner.

Click here to read more about the NIH Expanded Policy. . . . is changing the way applicants apply for grants

logo for grants dot gov is updating its process to make it easier for applicants to apply for federal grants. In December 2017, will phase out the Legacy Application Package, and applicants will instead apply through Workspace.

Read the full story about application changes on . . .


IRB marks 50 years of protecting the rights and welfare of human subjects at MMRF and HCMC

HSRC-IRB-50-resizedFor half a century, an Institutional Review Board (IRB) has been reviewing, approving and monitoring research involving human subjects at the Minneapolis Medical Research Foundation (MMRF) and Hennepin County Medical Center (HCMC).  When the IRB began in 1966, it was called the Research Advisory Committee. In 1987, it was renamed the Human Subjects Research Committee (HSRC). In July 2016, the board commemorated its 50th Anniversary.

Read more about IRB’s 50-year celebration. . . .


Watch the video to learn about our history