Research Program Catalog

 Berman Center for Outcomes & Clinical Research
Investigators: Anne Murray, MD, MSc; Mobin Malik, MD
Funding Types: Federal grants, Industry contracts
Approximate Staff Size: 15 people
Types of Staff: Investigators, Project Managers, Research Coordinators, Lab, CRAs

Program Description: Since its inception in 1965, the Berman Center has been a leader in cardiovascular research and a clinical site for over 100 trials in heart and kidney disease, diabetes, women’s health, cancer, aging, and neurological disorders.  The Berman Center is experienced in study design, implementation and analysis and has been -and is- a clinical site, an International Coordinating Center and Academic Research Organization (ARO).  As an ARO, Berman provides scientific rigor and credibility through partnerships with academia.  Berman has extensive experience proposing and recruiting sites through established networks and relationships and can implement all aspects associated with starting and managing a successful study.  As such, the Berman Center is ideally suited to guide new investigators in any and all aspects of clinical research or provide a research infrastructure for those investigators who may not currently have one.

 

Cardiology
Investigators: Brad Bart, MD; Woubeshet Ayenew, MD; Steve Goldsmith, MD
Funding Types: Federal grants, Industry contracts
Approximate Staff Size: 5 people
Types of Staff: Investigators, Research Manager, Research Coordinator

Program Description: The Cardiology Division conducts studies involving both early and late-phase trials of new drugs and devices, primarily in patients with acute and chronic heart failure, with the goal of improving outcomes. These studies include a mixture of individually-initiated projects, Federal studies and work with industry sponsors. The Division also has involvement with studies in the areas of preventive cardiology, nuclear imaging, and cardiac arrest/resuscitation science.

 

Chronic Disease Research Group (CDRG)
Investigators: David T. Gilbertson, PhD; Allan Collins, MD; James Wetmore, MD; Chuck Herzog, MD; Jiannong Liu, PhD; Jon Snyder, PhD; Craig Solid, PhD; Shuling Li, PhD; Suying Li, PhD
Funding Types: Federal contracts, Federal grants, Industry contracts
Approximate Staff Size: 50 people
Types of Staff: Investigators (MD and PhD), Biostatisticians (doctoral and MS level), Epidemiologists (doctoral), IT (programmers, information systems analysts), Project Managers, Publications

Program Description: CDRG currently holds the contract for the Scientific Registry of Transplant Recipients (SRTR), funded by HRSA, the Health Services and Resources Administration (part of the U.S. Department of Health and Human Services). The SRTR supports ongoing evaluation of the status of solid organ transplantation in the United States. From 1999 to 2014 CDRG served as the Coordinating Center for the United States Renal Data System (USRDS), administered by the NIH, and also ran the USRDS Cardiovascular Special Studies Center. Using large administrative health care datasets, CDRG conducts clinical and epidemiological health services research studies in a number of chronic disease areas, including nephrology, cardiology, transplantation, oncology, and osteoporosis. In each of these areas CDRG conducts surveillance, outcomes research, comparative effectiveness, pharmacoepidemiology, quality of care, and health economics and policy studies. Additional areas of expertise include communications/publications, as well as designing and running large data coordinating center activities.

 

Drug Addiction – Preclinical
Investigators: Paul Pentel, MD; Mark LeSage, PhD; Marco Pravetoni, PhD; Andrew Harris, PhD
Funding Types: Federal grants, Industry contracts
Approximate Staff Size: 15 people
Types of Staff: Investigators, Research Technicians/scientists, Post-doctoral Fellows, Graduate Students

 Program Description: The preclinical drug addiction research program uses preclinical models to understand pharmacokinetic, immunological, and behavioral mechanisms underlying addiction to nicotine and other drugs of abuse. Areas of interest include: a) development of vaccines or drug-specific antibodies as treatments for addiction, b) improving efficacy of vaccines for addiction or other chronic diseases (i.e., cancer) by understanding the underlying B and T cell biology, c) use of animal models to inform FDA regulation of tobacco products, and d) identifying behavioral and pharmacokinetic predictors of individual differences in vulnerability to drug addiction.

 

Drug Addiction – Clinical
Investigators: Gavin Bart, MD; Andrew Busch, PhD
Funding Types: Federal grants
Approximate Staff Size: 10 people
Types of Staff: Investigators, Project Manager, Research Coordinator, Research Associates

Program Description: Dr. Bart’s research goals address substance use disorders and the related global burden of disease. His current projects explore pharmacokinetic models for drug treatment, including the interaction of pharmacological treatments for drug addiction with antiretroviral therapies in the treatment of HIV.  Dr. Busch specializes in treating mood disorders and facilitating health behavior change (e.g., smoking cessation) in medical patients.  His current projects include a large-scale clinical trial targeting health behavior change in cardiac patients using Behavioral Activation (BA) counseling.

 

Emergency Medicine
Investigators: James Miner, MD; Johanna Moore, MD; Brian Driver, MD;Matthew Prekker, MD; Jon Cole, MD; Danielle Hart, MD; Paul Nystrom, MD; Jeffrey Ho, MD; Keith Lurie, MD
Funding Types: Federal grants, Industry contracts
Approximate Staff Size: 15 people
Types of Staff: 8 Investigators, 1 Project Manager, 6 Research Coordinators, ~40 Volunteer Research Associates

Program Description: The Emergency Medicine research program conducts a variety of studies all aimed at evaluating and improving outcomes in patients who visit the Emergency Department (ED). Areas of interest include pain, sedation, resuscitation, critical care, airway management, translational cardiac arrest research, educational research to improve training of future healthcare providers, use of force/intermediate weapon research, and psychobehavioral emergencies.

 

Gastroenterology
Investigators: Craig Peine, MD
Funding Types: Industry contracts
Approximate Staff Size: 4 people
Types of Staff: Investigators, Research Coordinators

Program Description: Dr. Peine’s general interests are in the mechanisms and treatment of chronic liver disease, including alcoholic hepatitis, autoimmune hepatitis and viral hepatitis.

 

General Surgery
Investigators: Ryan Fey, MD; Jon Gayken, MD; Rachel Nygaard, PhD; John Cumming, MD; Michael Hu, MD; Jon Krook, MD; Arthur Ney, MD; Chad Richardson, MD; Joan Van Camp, MD; Richard Zera, MD, PhD; Ellen Bernardson, APRN, CNP; Mark Hill, MD, PhD; Mark Odland, MD; Kendall Feia, MD; Ian Schwartz, MD; Philip Sweetser, MD
Funding Types: Federal grants, foundation grants, internal funding
Approximate Staff Size: 15 people
Types of Staff: Investigators, Research Director

Program Description: Investigators in the department of general surgery participate in research studies in a wide range of areas. As a level-one trauma center, a major area of focus is outcomes based research in trauma and critical care. Particular interests of investigators in the Burn Center include outcomes based research regarding frostbite injury and infection prevention following burn injury. The majority of recent projects in the Trauma division have focused on improving patient outcomes following traumatic injury in the pediatric and adult populations.

 

HIV Research (Positive Care Center)
Investigators: Keith Henry, MD; Jason Baker, MD, MS
Funding Types: Federal grants, Industry contracts
Approximate Staff Size: 8-10 people
Types of Staff: Investigators, Project Managers, Research Coordinator, Lab Technician

Program Description: Currently, the HIV research program is coordinating a variety of studies all aimed at improving and evaluating outcomes in patients with HIV. Dr. Baker’s primary research focus involves translational clinical studies emphasizing persistent inflammation and associated complications among HIV patients, with additional activities related to aging, cardiovascular disease, HIV prevention, and improving health outcomes. Dr. Henry participates in studies primarily focused on HIV treatment and prevention strategies, including novel and newly available therapies.

 

Internal Medicine
Investigators: Mark Linzer, MD; Kate Vickery, MD
Funding Types: Federal grants, foundation grants
Approximate Staff Size: 8-10 people
Types of Staff: Investigators, Project Manager, Project Coordinator, Research Assistant, Data Analyst

Program Description: The Division of Internal Medicine conducts research in a variety of areas with the overall goal of identifying ways to improve the delivery of healthcare from both the patient and the provider perspective. The researchers in this Division are conducting studies to better define the “burden of treatment” patients face as a result of their encounters with the healthcare system with the goal of identifying appropriate practice-based interventions to reduce disparities of care. From the provider perspective, their research is designed to identify and reduce stressors on medical providers (such as stress associated with utilizing electronic medical records) and identifying strategies for improvement and achieving better work/life balance.

 

Laboratory Medicine and Pathology
Investigators: Fred S. Apple PhD; Sara Love PhD; Glen T. Hansen, PhD
Funding Types: Predominately Industry grants and contracts
Approximate Staff Size: 12 people
Types of Staff Scientists, Medical Technologists, Research Nurses, Research Assistants, PhD Fellow, MD Cardiology Fellow, Senior Research Managers

Scientists, Medical Technologists, Research Nurses, Research Assistants, PhD Fellow, MD Cardiology Fellow, Senior Research Managers

Program Description: For the past 33 years, Dr. Apple’s patient centered interests have been focused in the translational, applied research areas of cardiac and vascular biomarkers for diagnostics and risk outcomes assessment in acute coronary syndrome, supply-demand pathophysiology, heart failure and exercise biochemistry. His lab has served as a core lab for both NIH and VA cooperative studies. His lab has worked closed with industry pertaining to 510k and PMA studies for assays and instrument clearance by the FDA for analytical and clinical use. In addition, Dr. Apple maintains an active research focus in forensic toxicology/postmortem analysis of drugs and ethanol. The CLIA-certified research laboratory is designated “Cardiac Biomarkers Trials Lab.” Dr. Love works closely with Dr. Apple leading the Cardiac Biomarkers Trials Lab. Dr. Hansen is the Director of Clinical Microbiology and Molecular Diagnostic and his research interests focus on the relationship between laboratory assay results and clinical decision making.

 

Nephrology/Clinical/Pre-clinical Research
Investigators: Bertram Kasiske, MD; Ajay Israni, MD, MS; Keith Eidman, MD
Funding Types: Federal grants
Approximate Staff Size: 5-10 people
Types of Staff: Investigators, Post-doctoral Fellows, Research Assistants

Program Description: Dr. Kasiske is conducting studies following the long-term outcomes for kidney donors to see if any complications arise later in their lives. Dr. Israni is interested in how genetic variability affects the long-term outcomes for the kidney recipients he has treated. The group is also involved in the development of new clinical guidelines for improving kidney disease treatment outcomes.

 

Neurology/NETT/Emergency Medicine
Investigators: U of MN Hub PI = Michelle Biros, MD, MS

U of MN Hub Co – PI = Mustapha Ezzeddine, MD

Funding Types: Federal grants
Approximate Staff Size: 6 people
Types of Staff: Research Coordinators, Project Managers, Administrative Assistants

Program Description: NETT is a national clinical trial network that participates in Phase III clinical trials to investigate interventions for acute neurological emergencies. The NETT is a national research network funded by NINDS, with 22 academic Hubs, each of which has many local “spokes,” which are community and academic institutions where enrollment into clinical trials occurs. HCMC is a Spoke of the U of MN Hub. The local U of MN Hub has up to 11 Spokes, including HCMC and sites throughout the Midwest, where clinical trials occur. The Hub provides infrastructure support to local research efforts involved in the NETT clinical trials. There is “traveling research team” on call to assist in screening, consenting and enrolling patients into any of the concurrent trials being done within the national and local network. There is an external service organization that can be hired to assist in preparing for trials, and to cover calls for enrollment into clinical trials.

 

Neurology/StrokeNet/Emergency Medicine
Investigators: U of MN Regional Coordinating Center (RCC) PI = Mustapha Ezzeddine, MD

U of MN RCC Co – PI = Michelle Biros, MD, MS

Funding Types: Federal grants
Approximate Staff Size: Overlaps with the NETT and shares staff and infrastructure resources
Types of Staff: Research Coordinators, Project Managers, Administrative Assistants

Program Description: StrokeNet is a clinical trial network that participates in clinical trials to investigate interventions throughout the spectrum of stroke, from prevention to rehabilitation.  The StrokeNet is a national research network funded by NINDS, with 25 academic Regional Coordinating Centers (RCC), each of which has many “satellites,” which are institutions where enrollment into clinical trials occurs. HCMC is a satellite of the U of MN RCC. The local U of MN RCC has several satellites including HCMC and sites throughout the region, where clinical trials occur. The RCC provides infrastructure support to local research efforts for the StrokeNet clinical trials. The program uses the NETT “traveling research team” on call to assist in screening, consenting and enrolling patients into any of the concurrent trials being done within the national and local StrokeNet network.

 

Neurosurgery/Traumatic Brain Injury
Investigators: Gaylan Rockswold, MD, PhD; Sarah Rockswold, MD; Uzma Samadani, MD
Funding Types: Federal grants
Approximate Staff Size: 15 people
Types of Staff: Investigators, Research Associate, Laboratory Technicians

Program Description: Major research focus is investigating the use of hyperbaric oxygen in the treatment of severe traumatic brain injury. Continued NIH funding for a multicenter randomized clinical trial is being sought. Second major focus of interest is visual dysfunction and its impact on outcome in TBI as well as the use of visual dysfunction in predicating the outcome of TBI.

 

Orthopaedics
Investigators: Andrew Schmidt, MD; David Templeman, MD; Thomas Varecka, MD; Richard Kyle, MD; Gudrun Mirick, MD; Nancy Luger, MD; Jackie Geissler, MD; Joan Bechtold, PhD; J.R. Westberg, BA
Funding Types: Federal grants and internal funding
Approximate Staff Size: 10 people
Types of Staff: Investigators, Biomechanical Engineer, Project Manager, Research Assistant

Program Description: The HCMC Orthopaedic department is a recognized leader in outcomes and basic research on issues related to orthopaedic injury, specifically focusing on trauma, adult reconstruction, and biomechanics. There are currently over 20 IRB approved projects that are active and in varying stages of completion. The studies are sponsored by HCMC, industry, and national research consortiums. The Orthopaedic Department also cofounded and benefits from collaboration with Excelen, a non-profit research and education organization that boasts an impressive biomechanics and skills lab.

HCMC is also one of the core centers of the nation-wide Major Extremity Trauma Research Consortium funded by the Department of Defense. The overall goal of the Consortium is to produce the evidence needed to establish treatment guidelines for the optimal care of the wounded warrior and ultimately improve the clinical, functional and quality of life outcomes of both service members and civilians who sustain high energy trauma to the extremities.

 

Pediatrics
Investigators: Julia Joseph DiCaprio, MD; Diana Cutts, MD; Tina Slusher, MD; Gail Brottman, MD
Funding Types: Federal grants, foundation grants
Approximate Staff Size: 5-10 people
Types of Staff: Investigators, Research Managers, Research Assistants

Program Description: Dr. Joseph-Di Caprio’s research focuses on clinic-based interventions intended to promote safer sex practices in teens. Dr. Cutts is currently involved in a multi-site study designed to measure the impact of welfare reform on hunger, growth, and general well-being of children under three years of age. She is also involved in leading the HCMC Therapeutic Food Pharmacy and reducing food insecurity in HCMC’s patients. Dr. Slusher’s research focuses on pediatric critical care, particularly in the recognition and treatment of neonatal hyperbilirubinemia through sunlight phototherapy (SPT).

Dr. Brottman’s research focuses on decreasing the disparities in the care of children with asthma including environmental tobacco smoke exposure and Pediatric Pulmonology.